What does cVDPV2 stand for?

What does cVDPV2 stand for?

• A. Circulating vaccine-derived poliovirus type 2
• B. Circulating viral disease derivation poliovirus 2
• C. Conserved vaccine-derived poliovirus 2
• D. Childhood vaccine-derived poliovirus 2

Answer: (A)

Understanding circulating vaccine-derived poliovirus type 2 means recognizing that a poliovirus can originate from the oral polio vaccine, circulate in under-immunized populations, and be classified by serotype. The “circulating” part indicates sustained transmission in the community, not just isolated cases. “Vaccine-derived” means the virus started as the attenuated vaccine strain, not a wild poliovirus. “Type 2” refers to the serotype of poliovirus. The oral vaccine uses live-attenuated virus; in populations with low immunity, this virus can mutate during transmission and regain neurovirulence, leading to illness similar to wild poliovirus. The other options use terms that don’t reflect this origin or the standard naming for poliovirus, so they don’t fit the established classification.

Understanding circulating vaccine-derived poliovirus type 2 means recognizing that a poliovirus can originate from the oral polio vaccine, circulate in under-immunized populations, and be classified by serotype. The “circulating” part indicates sustained transmission in the community, not just isolated cases. “Vaccine-derived” means the virus started as the attenuated vaccine strain, not a wild poliovirus. “Type 2” refers to the serotype of poliovirus. The oral vaccine uses live-attenuated virus; in populations with low immunity, this virus can mutate during transmission and regain neurovirulence, leading to illness similar to wild poliovirus. The other options use terms that don’t reflect this origin or the standard naming for poliovirus, so they don’t fit the established classification.